Article
A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain.
Neuroscience letters - 17 May 2002
Green E K, Thaker U, McDonagh A M, Iwatsubo T, Lambert J-C, Chartier-Harlin M-C, Harris J M, Pickering-Brown S M, Lendon C L, Mann D M A
Abstract excerpt
There are numerous polymorphisms within the tau gene but these are in complete linkage disequilibrium and exist as two common extended haplotypes H1 and H2. We have investigated the frequency of these haplotypes in 83 cases of sporadic Alzheimer's disease (AD) using the +34 polymorphism in intron 11 of the tau gene as a marker of H1 and H2 haplotypes. The total amount of hyperphosphorylated tau protein (tau...
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