Article
Fluorescence energy transfer monitored competitive equilibria of nucleic acids: applications in thermodynamics and screening.
Biopolymers - 1 Jan 2000
Plum G E, Breslauer K J
Abstract excerpt
Precise thermodynamic characterization of nucleic acid complex stability is required to understand a variety of biologically significant events as well as to exploit the specific recognition capabilities of nucleic acids in biotechnology, diagnostics, and therapeutics. The development of a database of nucleic acid thermodynamics with sufficient precision to foster further developments in these areas requires new...
Topics
- Binding, Competitive
- Energy Transfer
- Models, Biological
- Nucleic Acids
- Polymorphism, Single Nucleotide
- Spectrometry, Fluorescence
- Thermodynamics