Fluorescence energy transfer monitored competitive equilibria of nucleic acids: applications in thermodynamics and screening.

Abstract excerpt

Precise thermodynamic characterization of nucleic acid complex stability is required to understand a variety of biologically significant events as well as to exploit the specific recognition capabilities of nucleic acids in biotechnology, diagnostics, and therapeutics. The development of a database of nucleic acid thermodynamics with sufficient precision to foster further developments in these areas requires new...

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