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Association of Severe Noncerebral Plasmodium falciparum Malaria in Brazil With Expressed PfEMP1 DBL1α Sequences Lacking Cysteine Residues

1 Jan 2002

Abstract excerpt

BACKGROUND: Cytoadherence and rosetting contribute to the development of severe Plasmodium falciparum malaria. In Brazil,severe falciparum malaria is mostly associated with renal or pulmonary complications and very rarely with cerebral malaria. The most N-terminal DBL1 alpha domain of PfEMP1, a protein encoded by the var multigene family mediates rosetting. We analyzed parasites of Brazilian patients with severe...

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PMID: 11984002
DOI: 10.1007/bf03401999

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