Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?

Abstract excerpt

Human leukocyte antigen genes associated with rheumatoid arthritis are commonly found in the unaffected population, implying that causal mechanisms of disease involve interactions between these genes and other factors. A variety of approaches-genetic, structural, and immunologic-are used to explore possible molecular interactions that may contribute to understanding the basis for this disease association. The...

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