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Article

Experimental evidence that changes in oocyte growth influence meiotic chromosome segregation

1 May 2002

Abstract excerpt

BACKGROUND: It is well known that the fidelity of meiotic chromosome segregation is greatly reduced with increasing maternal age in humans. More recently, direct studies of human oocytes have demonstrated a striking age-related increase in oocytes exhibiting gross disturbances in chromosome alignment on the meiotic spindle. This abnormality, termed congression failure, has been postulated to be causally related...

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PMID: 11980735
DOI: 10.1093/humrep/17.5.1171

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