Article
Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
Zwaenepoel Ingrid, Mustapha Mirna, Leibovici Michel, Verpy Elisabeth, Goodyear Richard, Liu Xue Zhong, Nouaille Sylvie, Nance Walter E, Kanaan Moien, Avraham Karen B, Tekaia Fredj, Loiselet Jacques, Lathrop Marc, Richardson Guy, Petit Christine
Abstract excerpt
A 3,673-bp murine cDNA predicted to encode a glycosylphosphatidylinositol-anchored protein of 1,088 amino acids was isolated during a study aimed at identifying transcripts specifically expressed in the inner ear. This inner ear-specific protein, otoancorin, shares weak homology with megakaryocyte potentiating factor/mesothelin precursor. Otoancorin is located at the interface between the apical surface of the...
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