Article
Similar phenotypes caused by mutations in OTOG and OTOGL.
Ear and hearing - 1 Jan 2000
Oonk Anne M M, Leijendeckers Joop M, Huygen Patrick L M, Schraders Margit, del Campo Miguel, del Castillo Ignacio, Tekin Mustafa, Feenstra Ilse, Beynon Andy J, Kunst Henricus P M, Snik Ad F M, Kremer Hannie, Admiraal Ronald J C, Pennings Ronald J E
Abstract excerpt
OBJECTIVES: Recently, OTOG and OTOGL were identified as human deafness genes. Currently, only four families are known to have autosomal recessive hearing loss based on mutations in these genes. Because the two genes code for proteins (otogelin and otogelin-like) that are strikingly similar in structure and localization in the inner ear, this study is focused on characterizing and comparing the hearing loss caused...
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