Article
Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A <sub>2</sub>
22 Dec 1998
Abstract excerpt
The ability to sense orientation relative to gravity requires dense particles, called otoconia, which are localized in the vestibular macular organs. In mammals, otoconia are composed of proteins (otoconins) and calcium carbonate crystals in a calcite lattice. Little is known about the mechanisms that regulate otoconial biosynthesis. To begin to elucidate these mechanisms, we have partially sequenced and cloned...
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