[Basic approaches to anti-HIV resistance].

Abstract excerpt

Highly active antiretroviral therapy with reverse transcriptase inhibitors(RTIs) and protease inhibitors(PIs) has achieved high-level suppression of viral load in HIV-1-infected patients. However, drug-resistant HIV-1 mutants often emerge, resulting in treatment failure. Various research attempts have been made to overcome the drug-resistance. At present, more than 200 amino acid mutations that confer resistance...

Topics

• Anti-HIV Agents
• Antiretroviral Therapy, Highly Active
• Drug Resistance, Viral
• Genotype
• HIV Protease Inhibitors
• HIV-1
• Humans
• Mutation
• Phenotype
• Reverse Transcriptase Inhibitors