Article
The aristaless (Arx) gene: one gene for many "interneuronopathies".
Frontiers in bioscience (Elite edition) - 1 Jan 2010
Ruggieri Martino, Pavone Piero, Scapagnini Giovanni, Romeo Loriana, Lombardo Ilaria, Li Volti Giovanni, Corsello Giovanni, Pavone Lorenzo
Abstract excerpt
The ARX (Aristaless-related (X-linked) homeobox) gene is not only present in arthropods and their ancestors, but also in vertebrates including humans (ARX orthologs). The gene is composed of 5 coding exons and it is expressed predominantly in foetal and adult brain and skeletal muscle. In this review we report on our experience and review the existing literature on the genotype and phenotype heterogeneity...
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