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Article

The role of ARX in cortical development.

The European journal of neuroscience - 1 Feb 2006

Friocourt Gaëlle, Poirier Karine, Rakić Sonja, Parnavelas John G, Chelly Jamel

Abstract excerpt

The ARX protein (encoded by the aristaless-related homeobox gene) is a member of the paired class of homeoproteins. More precisely, it is a member of the Aristaless subclass of proteins with a glutamine residue (Q) at the critical position 50 of the homeodomain (Q50). Through identification of diverse inherited or de novo mutations, genetic investigations of X-linked mental retardation conditions have...

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Source

Identifiers

PMID: 16519652
DOI: 10.1111/j.1460-9568.2006.04629.x

Genes

ARX

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Related research

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Research trail→

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The role of ARX in cortical development.PMID 16519652Read ↗

Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons.Semantic proximity Read ↗

The aristaless (Arx) gene: one gene for many "interneuronopathies".Semantic proximity Read ↗

The ARX story (epilepsy, mental retardation, autism, and cerebral malformations): one gene leads to many phenotypes.Semantic proximity Read ↗

ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation.Semantic proximity Read ↗

Aristaless-related homeobox gene disruption leads to abnormal distribution of GABAergic interneurons in human neocortex: evidence based on a case of X-linked lissencephaly with abnormal genitalia (XLAG).Semantic proximity Read ↗

Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy.Semantic proximity Read ↗

ARX: a gene for all seasons.Semantic proximity Read ↗

A novel mutation in the aristaless domain of the ARX gene leads to Ohtahara syndrome, global developmental delay, and ambiguous genitalia in males and neuropsychiatric disorders in females.Semantic proximity Read ↗

Aristaless Related Homeobox (ARX) Interacts with β-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling.Semantic proximity Read ↗

Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1.Semantic proximity Read ↗

ARX spectrum disorders: making inroads into the molecular pathology.Semantic proximity Read ↗

X-linked mental retardation and epilepsy: pathogenetic significance of ARX mutations.Semantic proximity Read ↗

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