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Article

Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.

Proteins - 1 Mar 2012

Ahmad Jawid N, Li Jingjing, Biedermannová Lada, Kuchař Milan, Sípová Hana, Semerádtová Alena, Cerný Jiří, Petroková Hana, Mikulecký Pavel, Polínek Jiří, Staněk Ondřej, Vondrášek Jiří, Homola Jiří, Malý Jan, Osička Radim, Sebo Peter, Malý Petr

Abstract excerpt

Recombinant ligands derived from small protein scaffolds show promise as robust research and diagnostic reagents and next generation protein therapeutics. Here, we derived high-affinity binders of human interferon gamma (hIFNγ) from the three helix bundle scaffold of the albumin-binding domain (ABD) of protein G from Streptococcus G148. Computational interaction energy mapping, solvent accessibility assessment,...

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Identifiers

PMID: 22113774
DOI: 10.1002/prot.23234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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