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Article

Functional importance of the 3'-terminal adenosine of tRNA in ribosomal translation.

The Journal of biological chemistry - 5 Jul 2002

Virumae Kai, Saarma Urmas, Horowitz Jack, Remme Jaanus

Abstract excerpt

The universally conserved 3'-terminal CCA sequence of tRNA interacts with large ribosomal subunit RNA during translation. The functional importance of the interaction between the 3'-terminal nucleotide of tRNA and the ribosome was studied in vitro using mutant in vitro transcribed tRNA(Val) A76G. Val-tRNA(CCG) does not support polypeptide synthesis on poly(GUA) as a message. However, in a co-translation system,...

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PMID: 11967262
DOI: 10.1074/jbc.M200393200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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