Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages

1 May 2002

Abstract excerpt

Orf virus (ORFV) is the type species of the parapoxvirus genus and produces cutaneous pustular lesions in sheep, goats and humans. The genome encodes a polypeptide with remarkable homology to interleukin-10 (IL-10), particularly ovine IL-10, and also to IL-10-like proteins encoded by Epstein-Barr virus (EBV) and equine herpesvirus. IL-10 is a pleiotropic cytokine that can exert either immunostimulatory or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Poxvirus research and outbreaks
Share to Veterinary Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11961259
DOI: 10.1099/0022-1317-83-5-1049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophagesPMID 11961259Read ↗

A homolog of interleukin-10 is encoded by the poxvirus orf virusSemantic proximity Read ↗

A Novel Inhibitor of the NF-κB Signaling Pathway Encoded by the Parapoxvirus Orf VirusSemantic proximity Read ↗

Virus-Encoded Homologs of Cellular Interleukin-10 and Their Control of Host Immune FunctionSemantic proximity Read ↗

Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factorSemantic proximity Read ↗

Molecular Genetic Analysis of Orf Virus: A Poxvirus That Has Adapted to SkinSemantic proximity Read ↗

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factorSemantic proximity Read ↗

Potent Immunosuppressive Activities of Cytomegalovirus- Encoded Interleukin-10Semantic proximity Read ↗

Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteinsSemantic proximity Read ↗

Cytokine Homologs of Human GammaherpesvirusesSemantic proximity Read ↗

Interleukin‐10 in viral diseases and cancer: exiting the labyrinth?Semantic proximity Read ↗

Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon ResponseSemantic proximity Read ↗

Orf virus ORFV112, ORFV117 and ORFV127 contribute to ORFV IA82 virulence in sheep.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.