Article
The biological cost of mutational antibiotic resistance: any practical conclusions?
Current opinion in microbiology - 1 Oct 2006
Andersson Dan I
Abstract excerpt
A key parameter influencing the rate and trajectory of the evolution of antibiotic resistance is the fitness cost of resistance. Recent studies have demonstrated that antibiotic resistance, whether caused by target alteration or by other mechanisms, generally confers a reduction in fitness expressed as reduced growth, virulence or transmission. These findings imply that resistance might be reversible, provided...
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