Article
Regulation of the heme A biosynthetic pathway in Saccharomyces cerevisiae.
FEBS letters - 10 Apr 2002
Barros Mario H, Tzagoloff Alexander
Abstract excerpt
Biosynthesis of heme A, a prosthetic group of cytochrome oxidase (COX), involves an initial farnesylation of heme B. The heme O product formed in this reaction is modified by hydroxylation of the methyl group at carbon C-8 of the porphyrin ring. This reaction was proposed to be catalyzed by Cox15p, ferredoxin, and ferredoxin reductase. Oxidation of the alcohol to the corresponding aldehyde yields heme A. In the...
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