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Article

Heme A synthesis and CcO activity are essential for Trypanosoma cruzi infectivity and replication.

The Biochemical journal - 27 Jun 2017

Merli Marcelo L, Cirulli Brenda A, Menéndez-Bravo Simón M, Cricco Julia A

Abstract excerpt

Trypanosoma cruzi, the causative agent of Chagas disease, presents a complex life cycle and adapts its metabolism to nutrients' availability. Although T. cruzi is an aerobic organism, it does not produce heme. This cofactor is acquired from the host and is distributed and inserted into different heme-proteins such as respiratory complexes in the parasite's mitochondrion. It has been proposed that T. cruzi's...

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PMID: 28588043
DOI: 10.1042/BCJ20170084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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