Article
Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus.
Hepatology (Baltimore, Md.) - 1 Oct 1999
Christie J M, Chapel H, Chapman R W, Rosenberg W M
Abstract excerpt
How Hepatitis C Virus (HCV) causes persistent infection is unknown. One hypothesis is that HCV evades the host immune response through mutation in immune epitopes. We have investigated mutations in the HCV genome to see if they cluster within immune epitopes; and we have studied the effect of ant...
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