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Article

Distinct promoter usage of mdm2 gene in human breast cancer.

Oncology reports - 1 Jan 2000

Okumura Naoki, Saji Shigehira, Eguchi Hidetaka, Nakashima Shigeru, Saji Shigetoyo, Hayashi Shin-Ichi

Abstract excerpt

Human breast cancers, especially estrogen receptor alpha (ER(alpha))-positive ones, often overexpress the oncoprotein MDM2 without mdm2 gene amplification. The mdm2 gene is transcribed into two different mRNAs, namely L-mdm2 and S-mdm2, which are generated from promoters P1 (constitutive) and P2 (regulated by tumor suppressor p53), respectively. To cast light on the mechanisms of MDM2 overexpression, we measured...

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Share to Breast Neoplasms
Share to Estrogen Receptor alpha
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Receptors, Estrogen

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11956627

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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