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Article

MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.

Biochemical and biophysical research communications - 16 Feb 2001

Saji S, Okumura N, Eguchi H, Nakashima S, Suzuki A, Toi M, Nozawa Y, Saji S, Hayashi S

Abstract excerpt

Overexpression of the oncoprotein MDM2, a negative feedback regulator of p53, is often observed in breast cancer tissue and cell lines, particularly in those which express estrogen receptor alpha (ERalpha). In this study, we report a novel function of MDM2, i.e., as a positive regulator of ERalpha. This function does not involve p53. MDM2 overexpressing clones derived from the breast cancer cell line, MCF-7...

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Source

Identifiers

PMID: 11178989
DOI: 10.1006/bbrc.2001.4339

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells.PMID 11178989Read ↗

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p53-Independent Activities of MDM2 and Their Relevance to Cancer TherapySemantic proximity Read ↗

Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancerSemantic proximity Read ↗

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Estrogen Receptor-α Binds p53 Tumor Suppressor Protein Directly and Represses Its FunctionSemantic proximity Read ↗

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The Roles of MDM2 and MDMX in CancerSemantic proximity Read ↗

p53, a Target of Estrogen Receptor (ER) α, Modulates DNA Damage-induced Growth Suppression in ER-positive Breast Cancer CellsSemantic proximity Read ↗

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