Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombopoietic stimulating activity of rhTyrRS (Y341A).

Scientific reports - 22 Sept 2017

Jinchao Yu, Yanling Zhang, Xu Wang, Bing Zhao, Yuhao Ye, Weiran Zhou, Shaoyang Sun, Liyun Ma, Yun Shi, Ling Zhan, Min Yu, Wei Mo

Abstract excerpt

Tumor radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts. Thrombocytopenia is a common disease. Some studies have shown that tRNA synthetase plays not only catalytic tRNA aminoacylation roles, but also functions similarly to cytokines. Recombinant human tyrosyl-tRNA synthetase with a mutated Y341A (rhTyrRS (Y341A)) promotes megakaryocyte migrate from bone marrow to peripheral blood. It...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Megakaryocytes

Share to Platelet Count

Share to Radiotherapy

Share to Thrombocytopenia

Share to Thrombopoiesis

Share to Tyrosine-tRNA Ligase

Source

Open in PubMed Open full text

Identifiers

PMID: 28939876
DOI: 10.1038/s41598-017-12073-4
PMCID: PMC5610193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombopoietic stimulating activity of rhTyrRS (Y341A).PMID 28939876Read ↗

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndromeSemantic proximity Read ↗

Paclitaxel improves thrombopoiesis in the absence of thrombopoietin receptor (Mpl).Semantic proximity Read ↗

Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1Semantic proximity Read ↗

Loss-of-function mutations in PTPRJ cause a new form of inherited thrombocytopeniaSemantic proximity Read ↗

The role of Tyro 3 subfamily receptors in the regulation of hemostasis and megakaryocytopoiesis.Semantic proximity Read ↗

The Y14-p53 Regulatory Circuit in Megakaryocyte Differentiation and ThrombocytopeniaSemantic proximity Read ↗

Reprogramming Megakaryocyte Gene Expression to Release Platelet-Like Particles with Opposite Biological Activities: Carrying Single-Chain Thromboxane A2 Receptor-G-Protein Complex with Therapeutic PotentialsSemantic proximity Read ↗

Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish ThrombopoiesisSemantic proximity Read ↗

Thrombopoietin knock-in augments platelet generation from human embryonic stem cellsSemantic proximity Read ↗

Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation.Semantic proximity Read ↗

Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride is a Safe and Effective Antithrombotic TherapySemantic proximity Read ↗

The Hippo pathway regulates human megakaryocytic differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.