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Article

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2002

Sakuma Rui, Ohnishi Yi Yu-ichiro, Meno Chikara, Fujii Hideta, Juan Hou, Takeuchi Jun, Ogura Toshihiko, Li En, Miyazono Kohei, Hamada Hiroshi

Abstract excerpt

BACKGROUND: Two TGFbeta-related proteins, Nodal and Lefty, are implicated in early embryonic patterning of vertebrates. Genetic data suggest that Nodal is a signalling molecule, while Lefty is an antagonist of Nodal, but their precise function remains unknown. RESULTS: The signalling pathway of N...

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Identifiers

PMID: 11952836
DOI: 10.1046/j.1365-2443.2002.00528.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11952836-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.PMID 11952836Read ↗

Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloidsSemantic proximity Read ↗

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.Semantic proximity Read ↗

Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish.Semantic proximity Read ↗

Lefty proteins are long-range inhibitors of squint-mediated nodal signaling.Semantic proximity Read ↗

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.Semantic proximity Read ↗

Cripto localizes Nodal at the limiting membrane of early endosomes.Semantic proximity Read ↗

Lefty antagonism of Squint is essential for normal gastrulation.Semantic proximity Read ↗

Nodal·Gdf1 Heterodimers with Bound Prodomains Enable Serum-independent Nodal Signaling and Endoderm DifferentiationSemantic proximity Read ↗

Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction.Semantic proximity Read ↗

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.Semantic proximity Read ↗

Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.Semantic proximity Read ↗

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.Semantic proximity Read ↗

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