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Article

Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?

DNA repair - 1 Jun 2008

Brooks P J, Cheng Tsu-Fan, Cooper Lori

Abstract excerpt

The classic model for neurodegeneration due to mutations in DNA repair genes holds that DNA damage accumulates in the absence of repair, resulting in the death of neurons. This model was originally put forth to explain the dramatic loss of neurons observed in patients with xeroderma pigmentosum n...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18339586
DOI: 10.1016/j.dnarep.2008.01.017
PMCID: PMC2408373

Genes

TREX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18339586-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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