Leukemia-associated gene rearrangements in blood mononuclears of subjects in long terms after radiation exposure.

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Article

Leukemia-associated gene rearrangements in blood mononuclears of subjects in long terms after radiation exposure.

Journal of experimental & clinical cancer research : CR - 1 Mar 2000

Butenko Z A, Smirnova I A, Zak K P, Kishinskaja E G, Janok E A

Abstract excerpt

The results of electron microscopy and molecular genetic study of blood mononuclears of 220 clean-up workers after 7-10 years since Chernobyl accident are presented. An increase of lymphocytes with altered ultrastructure of nuclei and membrane has been observed. Structural polymorphism of leukemia associated bcr and rRNA genes has been analyzed using Southern blot hybridization. Allelic polymorphism of bcr gene...

Topics

Gene Rearrangement
Genetic Predisposition to Disease
Humans
Leukemia, Radiation-Induced
Leukocytes, Mononuclear
Power Plants
Radioactive Hazard Release
Time Factors
Ukraine

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Open in PubMed

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PMID: 10840937

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