Article
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002
Friedler Assaf, Hansson Lars O, Veprintsev Dmitry B, Freund Stefan M V, Rippin Thomas M, Nikolova Penka V, Proctor Mark R, Rüdiger Stefan, Fersht Alan R
Abstract excerpt
Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding protein, binds to p53 core domain and stabilizes it in vitro. NMR studies showed that CDB3 bound to...
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