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Article

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.

Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2003

Issaeva Natalia, Friedler Assaf, Bozko Przemyslaw, Wiman Klas G, Fersht Alan R, Selivanova Galina

Abstract excerpt

We designed a series of nine-residue peptides that bound to a defined site on the tumor suppressor p53 and stabilized it against denaturation. To test whether the peptides could act as chaperones and rescue the tumor-suppressing function of oncogenic mutants of p53 in living cells, we treated human tumor cells with the fluorescein-labeled peptide Fl-CDB3 (fluorescent derivative of CDB3). Before treatment, the...

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Identifiers

PMID: 14595027
DOI: 10.1073/pnas.1835733100
PMCID: PMC263793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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