Article
Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999
Fleming R E, Migas M C, Zhou X, Jiang J, Britton R S, Brunt E M, Tomatsu S, Waheed A, Bacon B R, Sly W S
Abstract excerpt
Hereditary hemochromatosis (HH) is a common autosomal recessive disorder characterized by tissue iron deposition secondary to excessive dietary iron absorption. We recently reported that HFE, the protein defective in HH, was physically associated with the transferrin receptor (TfR) in duodenal crypt cells and proposed that mutations in HFE attenuate the uptake of transferrin-bound iron from plasma by duodenal...
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