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Article

Heterogeneous methylation and deletion patterns of the INK4a/ARF locus within prostate carcinomas.

The American journal of pathology - 1 Apr 2002

Konishi Noboru, Nakamura Mitsutoshi, Kishi Munehiro, Nishimine Masayoshi, Ishida Eiwa, Shimada Keiji

Abstract excerpt

To elucidate the role of p53/p16(INK4a)/RB1 pathways in prostate carcinogenesis, we analyzed the p14(ARF), p16(INK4a), RB1, p21(Waf1), p27(Kip1), PTEN, p73, p53, and MDM2 gene status of multiple areas within 16 histologically heterogeneous prostate carcinomas using methylation-specific polymerase...

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Topics

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Share to Carcinoma
Share to Cyclin-Dependent Kinase Inhibitor p16
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Neoplasm Proteins

Share to Prostatic Neoplasms

Share to Tumor Suppressor Protein p14ARF

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 11943705
DOI: 10.1016/S0002-9440(10)62547-3
PMCID: PMC1867197

Genes

MDM2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11943705-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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