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Article

Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in <i>BUB1</i> and <i>BUBR1</i>

1 Mar 2002

Abstract excerpt

OBJECTIVE: Thyroid follicular adenomas (FA) and carcinomas (FC) have a high prevalence of aneuploidy. We examined the contribution of mitotic checkpoint dysfunction and mutations of BUB1 or BUBR1, components of the spindle assembly checkpoint pathway, to chromosomal instability in thyroid cancer. DESIGN: The integrity of the mitotic checkpoint was studied in 8 aneuploid thyroid tumour cell lines. All cell lines...

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Identifiers

PMID: 11940046
DOI: 10.1046/j.1365-2265.2002.01475.x

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