Article
Budding uninhibited by benzimidazoles 1 might be a poor prognosis biomarker promoting the progression of papillary thyroid cancer.
Environmental toxicology - 1 Sept 2023
Jiang Wenjie, Yu Yan, Bhandari Adheesh, Hirachan Suzita, Dong Xubin, Huang Xiaoli, Qu Jinmiao, Chen Chengze
Abstract excerpt
BACKGROUND: Papillary thyroid carcinoma (PTC) is one of the most widespread malignant tumors of the endocrine system, with a high incidence. Budding uninhibited by benzimidazoles 1 (BUB1), one of the spindle assembly checkpoint (SAC) genes, is a multitask protein kinase required for eukaryotic chromosome segregation. Although BUB1 has been explored in several types of cancer, its biological role and molecular...
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