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Article

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Nature neuroscience - 1 Mar 2009

Carlén Marie, Meletis Konstantinos, Göritz Christian, Darsalia Vladimer, Evergren Emma, Tanigaki Kenji, Amendola Mario, Barnabé-Heider Fanie, Yeung Maggie S Y, Naldini Luigi, Honjo Tasuku, Kokaia Zaal, Shupliakov Oleg, Cassidy Robert M, Lindvall Olle, Frisén Jonas

Abstract excerpt

Neurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis under normal conditions in mice but instead gave rise to neuroblasts and astrocytes in response to stroke. Ependymal cell quiescence was actively maintained by canonical Notch signaling....

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PMID: 19234458
DOI: 10.1038/nn.2268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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