Article
Sources of variability and effect of experimental approach on expression profiling data interpretation.
BMC bioinformatics - 1 Jan 2002
Bakay Marina, Chen Yi-Wen, Borup Rehannah, Zhao Po, Nagaraju Kanneboyina, Hoffman Eric P
Abstract excerpt
BACKGROUND: We provide a systematic study of the sources of variability in expression profiling data using 56 RNAs isolated from human muscle biopsies (34 Affymetrix MuscleChip arrays), and 36 murine cell culture and tissue RNAs (42 Affymetrix U74Av2 arrays). RESULTS: We studied muscle biopsies from 28 human subjects as well as murine myogenic cell cultures, muscle, and spleens. Human MuscleChip arrays (4,601...
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