Article

Experimental reproducibility limits the correlation between mRNA and protein abundances in tumour proteomic profiles

2021-09-22

Abstract excerpt

Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to what extent this moderate correlation reflects post-transcriptional regulation and to what extent it reflects measurement error. Here, by analysing replicate profiles of tumours and cell lines, we show that there is considerable variation in the reproducibility of measurements of t...

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Literature Corpus work: f79f1178-88e1-55cb-94b1-55236a19cfe7
DOI: 10.1101/2021.09.22.461108

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