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Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells

25 Oct 2007

Abstract excerpt

In mammals, complementary contributions of both the maternal and the paternal genomes are required for normal development because of the parental-allele-specific modification of the genome, called genomic imprinting. Therefore, parthenogenetic embryos (PG) with two maternal genomes cannot develop to term, and PG chimeras show a restricted cell contribution of donor cells and reduced weight, although they can...

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PMID: 17962706
DOI: 10.1634/stemcells.2006-0635

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