Article
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides.
Protein engineering - 1 Mar 2002
Sawai Monali V, Waring Alan J, Kearney William R, McCray Paul B, Forsyth William R, Lehrer Robert I, Tack Brian F
Abstract excerpt
We studied three model antibacterial peptides that resembled the N-terminal 18 amino acids of SMAP-29, an alpha-helical, antimicrobial peptide of sheep. Although the parent compound, ovispirin-1 (KNLRR IIRKI IHIIK KYG), was potently antimicrobial, it was also highly cytotoxic to human epithelial cells and hemolytic for human erythrocytes. Single residue substitutions to ovispirin-1 yielded two substantially less...
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