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Article

Structure-Activity Relationship-based Optimization of Small Temporin-SHf Analogs with Potent Antibacterial Activity.

ACS chemical biology - 16 Oct 2015

André Sonia, Washington Shannon K, Darby Emily, Vega Marvin M, Filip Ari D, Ash Nathaniel S, Muzikar Katy A, Piesse Christophe, Foulon Thierry, O'Leary Daniel J, Ladram Ali

Abstract excerpt

Short antimicrobial peptides represent attractive compounds for the development of new antibiotic agents. Previously, we identified an ultrashort hydrophobic and phenylalanine-rich peptide, called temporin-SHf, representing the smallest natural amphibian antimicrobial peptide known to date. Here, we report on the first structure-activity relationship study of this peptide. A series of temporin-SHf derivatives...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26181487
DOI: 10.1021/acschembio.5b00495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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