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Article

In vitro evolution of recognition specificity mediated by SH3 domains reveals target recognition rules.

The Journal of biological chemistry - 14 Jun 2002

Panni Simona, Dente Luciana, Cesareni Gianni

Abstract excerpt

We have designed a repertoire of 10(7) different SH3 domains by grafting the residues that are represented in the binding surfaces of natural SH3 domains onto the scaffold of the human Abl-SH3 domain. This phage-displayed library was screened by affinity selection for SH3 domains that bind to the...

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Identifiers

PMID: 11929862
DOI: 10.1074/jbc.M109788200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11929862-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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