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Article

In vitro evolution of recognition specificity mediated by SH3 domains reveals target recognition rules.

The Journal of biological chemistry - 14 Jun 2002

Panni Simona, Dente Luciana, Cesareni Gianni

Abstract excerpt

We have designed a repertoire of 10(7) different SH3 domains by grafting the residues that are represented in the binding surfaces of natural SH3 domains onto the scaffold of the human Abl-SH3 domain. This phage-displayed library was screened by affinity selection for SH3 domains that bind to the synthetic peptides, APTYPPPLPP and LSSRPLPTLPSP, which are peptide ligands for the human Abl or Src SH3 domains,...

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Identifiers

PMID: 11929862
DOI: 10.1074/jbc.M109788200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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