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Article

Epitope-specific Evolution of Human CD8<b>+</b> T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection

1 Apr 2002

Abstract excerpt

Primary virus infection often elicits a large CD8(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between these two virus-specific populations is not well understood. Here we follow the human CD8(+) T cell response to Epstein-Barr virus (EBV) from its primary phase in infectious mononucleosis (IM) through to the persistent carrier state. Using HLA-A2.1 or B8...

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PMID: 11927633
DOI: 10.1084/jem.20011692

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