Article
MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response.
The Journal of experimental medicine - 6 May 2013
Long Heather M, Chagoury Odette L, Leese Alison M, Ryan Gordon B, James Eddie, Morton Laura T, Abbott Rachel J M, Sabbah Shereen, Kwok William, Rickinson Alan B
Abstract excerpt
Virus-specific CD4(+) T cells are key orchestrators of host responses to viral infection yet, compared with their CD8(+) T cell counterparts, remain poorly characterized at the single cell level. Here we use nine MHC II-epitope peptide tetramers to visualize human CD4(+) T cell responses to Epstein-Barr virus (EBV), the causative agent of infectious mononucleosis (IM), a disease associated with large...
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