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Article

c-fos regulates neuronal excitability and survival.

Nature genetics - 1 Apr 2002

Zhang Jianhua, Zhang Dongsheng, McQuade Jill Slane, Behbehani Michael, Tsien Joe Z, Xu Ming

Abstract excerpt

Excitotoxicity is a process in which glutamate or other excitatory amino acids induce neuronal cell death. Accumulating evidence suggests that excitotoxicity may contribute to human neuronal cell loss caused by acute insults and chronic degeneration in the central nervous system. The immediate early gene (IEG) c-fos encodes a transcription factor. The c-Fos proteins form heterodimers with Jun family proteins, and...

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Source

Identifiers

PMID: 11925568
DOI: 10.1038/ng859

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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c-fos regulates neuronal excitability and survival.PMID 11925568Read ↗

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