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Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion

1 Mar 2002

Abstract excerpt

The rickettsial pathogen Anaplasma marginale establishes lifelong persistent infection in the mammalian reservoir host, during which time immune escape variants continually arise in part because of variation in the expressed copy of the immunodominant outer membrane protein MSP2. A key question is how the small 1.2 Mb A. marginale genome generates sufficient variants to allow long-term persistence in an...

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PMID: 11918803
DOI: 10.1046/j.1365-2958.2002.02792.x

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