Article
Insights into mechanisms of bacterial antigenic variation derived from the complete genome sequence of Anaplasma marginale.
Annals of the New York Academy of Sciences - 1 Oct 2006
Palmer Guy H, Futse James E, Knowles Donald P, Brayton Kelly A
Abstract excerpt
Persistence of Anaplasma spp. in the animal reservoir host is required for efficient tick-borne transmission of these pathogens to animals and humans. Using A. marginale infection of its natural reservoir host as a model, persistent infection has been shown to reflect sequential cycles in which antigenic variants emerge, replicate, and are controlled by the immune system. Variation in the immunodominant...
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