Antigenic Variation of Anaplasma Marginale : Major Surface Protein 2 Diversity during Cyclic Transmission between Ticks and Cattle

Abstract excerpt

The rickettsial pathogen Anaplasma marginale expresses a variable immunodominant outer membrane protein, major surface protein 2 (MSP2), involved in antigenic variation and long-term persistence of the organism in carrier animals. MSP2 contains a central hypervariable region of about 100 amino acids that encodes immunogenic B-cell epitopes that induce variant-specific antibodies during infection. Previously, we...

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