Article
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Diabetes - 1 Apr 2002
Netherton Stuart J, Jimmo Sandra L, Palmer Daniel, Tilley Douglas G, Dunkerley Heather A, Raymond Daniel R, Russell James C, Absher P Marlene, Sage E Helene, Vernon Robert B, Maurice Donald H
Abstract excerpt
Cardiovascular diseases represent a significant cause of morbidity and mortality in diabetes. Of the many animal models used in the study of non-insulin-dependent (type 2) diabetes, the JCR:LA-cp rat is unique in that it develops insulin resistance in the presence of obesity and manifests both peripheral and coronary vasculopathies. In this animal model, arterial vascular smooth muscle cells (VSMCs) from...
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