Article
Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats.
British journal of pharmacology - 1 May 1998
McKendrick J D, Salas E, Dubé G P, Murat J, Russell J C, Radomski M W
Abstract excerpt
1. The effects of nitric oxide (NO) on vascular reactivity and platelet function in the obese (cp/cp) and lean (+/?) JCR:LA-cp rats were investigated. 2. Phenylephrine (PE; 0.1 nM-10 microM) induced contraction of isolated aortic rings in both genotypes (cp/cp and +/?) of JCR:LA-cp rats. The sens...
Topics
- Acetylcholine
- Animals
- Aorta, Thoracic
- Blood Platelets
- Blood Pressure
- Cyclic GMP
- Diabetes Mellitus
- Enzyme Inhibitors
- Genotype
- Insulin Resistance
- Muscle Contraction
- Muscle, Smooth, Vascular
- NG-Nitroarginine Methyl Ester
- Nitric Oxide
- Nitric Oxide Synthase
- Obesity
- Penicillamine
- Phenylephrine