Article
Body mass index and acid phosphatase locus 1 in diabetic disorders.
Acta diabetologica - 1 Dec 2010
Gloria-Bottini F, Magrini A, Di Renzo L, De Lorenzo A, Bergamaschi A, Bottini E
Abstract excerpt
The polymorphic enzyme acid phosphatase locus 1 (ACP1) is a candidate gene for obesity disorders. The enzyme is able to dephosphorylate the insulin receptor. Our group has observed a lower plasma glucose level in diabetic subjects carrying the low activity ACP1 phenotypes A and BA, and a positive association between these genotypes and body mass index (BMI). We have now analysed the relationship between BMI and...
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