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Article

Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors.

The Journal of biological chemistry - 31 May 2002

Lewicki Daniel N, Gallagher Thomas M

Abstract excerpt

Oligomeric spike (S) glycoproteins extend from coronavirus membranes. These integral membrane proteins assemble within the endoplasmic reticulum of infected cells and are subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2 fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind carcinoembryonic antigen-related cell adhesion molecule (CEACAM)...

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Identifiers

PMID: 11912215
DOI: 10.1074/jbc.M201837200
PMCID: PMC8060896

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Source receipt: pubmed, retrieved 7 Sept 2026.

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