Article
STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study.
Human molecular genetics - 15 Mar 2002
Duetsch Gabriele, Illig Thomas, Loesgen Sabine, Rohde Klaus, Klopp Norman, Herbon Nicole, Gohlke Henning, Altmueller Janine, Wjst Matthias
Abstract excerpt
The human signal transducer and activator of transcription 6 (STAT6) gene represents one of the most promising candidate genes for asthma and other inflammatory diseases on the chromosomal region 12q13-q24. Therefore we screened all 23 exons, including parts of the neighbouring introns, as well as the promoter region for common polymorphisms and tested them for linkage/association with asthma and related traits...
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