Article
CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?
Cancer letters - 6 Jun 2002
Berstein Lev M, Imyanitov Evgeny N, Gamajunova Vera B, Kovalevskij Anatolij Ju, Kuligina Ekatherina Sh, Belogubova Evgeniya V, Buslov Konstantin G, Karpova Maria B, Togo Alexandr V, Volkov Oleg N, Kovalenko Irina G
Abstract excerpt
Initiation and/or promotion of endometrial cancer is known to be associated with estrogen and androgen (androstenedione) excess as well as with hyperinsulinemia/insulin resistance. It is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility. We evaluated here the role of CYP17 biallelic (MspAI) polymorphism in 114...
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