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Article

Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity.

Cellular & molecular immunology - 1 May 2021

Sogkas Georgios, Atschekzei Faranaz, Adriawan Ignatius Ryan, Dubrowinskaja Natalia, Witte Torsten, Schmidt Reinhold Ernst

Abstract excerpt

In addition to susceptibility to infections, conventional primary immunodeficiency disorders (PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as lymphoproliferative and/or autoimmune disease. Autoimmunity can be the prominent phenotype of PIDs and commonly includes cytopenias and rheumatological diseases, such as arthritis, systemic lupus erythematosus (SLE), and Sjogren's...

Topics

Autoimmunity
Genetic Predisposition to Disease
Humans
Immune System Diseases
Immune Tolerance
Receptors, Antigen, T-Cell
T-Lymphocytes, Regulatory

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33795850
DOI: 10.1038/s41423-020-00626-z
PMCID: PMC8015752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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